Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy

Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy

Nuclear speckles are essential nuclear compartments involved in the assembly, delivery and recycling of pre-mRNA processing factors, and in the post-transcriptional processing of pre-mRNAs. Oculopharyngeal muscular dystrophy (OPMD) is caused by a small expansion of the polyalanine tract in the poly(...

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Bibliographic Details
Main Authors: Rocío Bengoechea, Olga Tapia, Iñigo Casafont, José Berciano, Miguel Lafarga, María T. Berciano
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Oculopharyngeal muscular dystrophy
Skeletal myofibers
Intranuclear inclusions
Nuclear speckles
Pre-mRNA processing
Poly(A)-binding protein nuclear 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000071

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http://www.sciencedirect.com/science/article/pii/S0969996112000071

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