Activated Phosphatidylinositol 3-Kinase/Akt Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells by Regulating the Forkhead Box Subgroup O-3a Signaling

Activated Phosphatidylinositol 3-Kinase/Akt Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells by Regulating the Forkhead Box Subgroup O-3a Signaling

Background and Aims: Endothelial progenitor cells (EPCs) differentiate into mature endothelial cells and may thus be candidates for ischemic disease therapy; however, the transition of EPCs to mesenchymal cells is not fully understood. We explored the role of phosphatidylinositol 3-kinase (PI3K)/Akt...

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Bibliographic Details
Main Authors: Zongqi Zhang, Tiantian Zhang, Yaoyao Zhou, Xiaowei Wei, Jianbing Zhu, Junfeng Zhang, Changqian Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Endothelial progenitor cell
Endothelial-to-mesenchymal transition
Phosphatidylinositol 3-kinase
PIK3R2
FoxO3a
Online Access:http://www.karger.com/Article/FullText/373978

Internet

http://www.karger.com/Article/FullText/373978

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