IVIg and LPS Co-stimulation Induces IL-10 Production by Human Monocytes, Which Is Compromised by an FcγRIIA Disease-Associated Gene Variant

IVIg and LPS Co-stimulation Induces IL-10 Production by Human Monocytes, Which Is Compromised by an FcγRIIA Disease-Associated Gene Variant

Intravenous Immunoglobulin (IVIg) is used to treat autoimmune or inflammatory diseases, but its mechanism of action is not completely understood. We asked whether IVIg can induce interleukin-10 (IL-10) and reduce pro-inflammatory cytokine production in human monocytes, and whether this response is r...

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Bibliographic Details
Main Authors: Lisa K. Kozicky, Susan C. Menzies, Zheng Yu Zhao, Tariq Vira, Kiera Harnden, Kwestan Safari, Kate L. Del Bel, Stuart E. Turvey, Laura M. Sly
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
IVIg
IL-10
monocyte
MAPK
ERK
p38
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02676/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02676/full

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