Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.

BACKGROUND:Small-molecules that disrupt the binding between glucokinase and glucokinase regulatory protein (GKRP) in the liver represent a potential new class of glucose-lowering drugs. It will, however, take years before their effects on clinically relevant cardiovascular endpoints are known. The p...

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Bibliographic Details
Main Authors: Pomme I H G Simons, Nynke Simons, Coen D A Stehouwer, Casper G Schalkwijk, Nicolaas C Schaper, Martijn C G J Brouwers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6198948?pdf=render