Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Tumor hypoxia plays an active role in promoting tumor progression, malignancy, and resistance to therapy in PDAC. We present evidence that nab-paclitaxel–gemcitabine (NPG) and/or a hypoxic tumor microenvironme...

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Bibliographic Details
Main Authors: Iman M. Ahmad, Alicia J. Dafferner, Kelly A. O’Connell, Kamiya Mehla, Bradley E. Britigan, Michael A. Hollingsworth, Maher Y. Abdalla
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
heme oxygenase-1
PDAC
chemotherapy
immune cells
Online Access:https://www.mdpi.com/2072-6694/13/9/2264

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https://www.mdpi.com/2072-6694/13/9/2264

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