Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

Abstract Background The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a synergistic anti-tumor effect with conventional chemotherapy agents. In...

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Bibliographic Details
Main Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee, Jeung-Whan Han
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Rosmarinic acid methyl ester
S6K1
Autophagy
Apoptosis
Cervical cancer
Cisplatin resistance
Online Access:http://link.springer.com/article/10.1186/s12885-019-5997-2

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http://link.springer.com/article/10.1186/s12885-019-5997-2

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