Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice
<p>Abstract</p> <p>Background</p> <p>Previously, we found that interleukin (IL)-18 deficiency aggravates kainic acid (KA)-induced hippocampal neurodegeneration in young C57BL/6 mice due to an over-compensation by IL-12. Additionally, IL-18 participates in fundamental in...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2010-04-01
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Series: | Journal of Neuroinflammation |
Online Access: | http://www.jneuroinflammation.com/content/7/1/26 |