Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice

Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice

<p>Abstract</p> <p>Background</p> <p>Previously, we found that interleukin (IL)-18 deficiency aggravates kainic acid (KA)-induced hippocampal neurodegeneration in young C57BL/6 mice due to an over-compensation by IL-12. Additionally, IL-18 participates in fundamental in...

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Bibliographic Details
Main Authors: Mix Eilhard, Quezada Hernan, Jin Tao, Zhang Xing-Mei, Winblad Bengt, Zhu Jie
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/7/1/26

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