Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells.

Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells.

The transcription factor Sp1 is implicated in the activation of G0/G1 phase genes. Modulation of Sp1 transcription activities may affect G1-S checkpoint, resulting in changes in cell proliferation. In this study, our results demonstrated that activated poly(ADP-ribose) polymerase 1 (PARP-1) promoted...

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Bibliographic Details
Main Authors: Liu Yang, Kun Huang, Xiangrao Li, Meng Du, Xiang Kang, Xi Luo, Lu Gao, Cheng Wang, Yanqing Zhang, Chun Zhang, Qiangsong Tong, Kai Huang, Fengxiao Zhang, Dan Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3868549?pdf=render

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http://europepmc.org/articles/PMC3868549?pdf=render

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