ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-κB activation.

ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-κB activation.

BACKGROUND: Activating transcription factor 3 (ATF3) is a negative regulator of proinflammatory cytokine expression in macrophages, and ATF3 deficient mice are more susceptible to endotoxic shock. This study addresses the role of ATF3 in the Kdo(2)-Lipid A-induced Toll-like receptor 4 (TLR4) signali...

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Bibliographic Details
Main Authors: Eun-Young Kim, Hye Young Shin, Joo-Young Kim, Dong-Gun Kim, Yong-Min Choi, Hyuk-Kwon Kwon, Dong-Kwon Rhee, You-Sun Kim, Sangdun Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2996292?pdf=render

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http://europepmc.org/articles/PMC2996292?pdf=render

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