Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage

Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage

Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the <i>NPC1</i> gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological component, the pathophysiology o...

Full description

Bibliographic Details
Main Authors: Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
liver damage
Niemann Pick type C disease
lysosomal storage disorder
proteomic analysis
mass spectrometry
Online Access:https://www.mdpi.com/2073-4409/10/8/2159

Internet

https://www.mdpi.com/2073-4409/10/8/2159

Similar Items