Gut Microbiota and Bacterial DNA Suppress Autoimmunity by Stimulating Regulatory B Cells in a Murine Model of Lupus

Gut Microbiota and Bacterial DNA Suppress Autoimmunity by Stimulating Regulatory B Cells in a Murine Model of Lupus

Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute to disease exacerbation. We previously showed the suppressive effect of vancomycin treatment during the “act...

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Bibliographic Details
Main Authors: Qinghui Mu, Michael R. Edwards, Brianna K. Swartwout, Xavier Cabana Puig, Jiangdi Mao, Jing Zhu, Joe Grieco, Thomas E. Cecere, Meeta Prakash, Christopher M. Reilly, Christopher Puglisi, Prathyusha Bachali, Amrie C. Grammer, Peter E. Lipsky, Xin M. Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
immunoregulation
gut microbiota
autoimmunity
bacterial DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593353/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.593353/full

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