Incurred sample stability of ASP3258 in the presence of its acyl glucuronide
The acyl glucuronide (AG) of ASP3258 was abundant in incurred monkey samples, and because an AG generally back-converts to its aglycone, accurate quantification of ASP3258 in monkey plasma was a challenge. To prevent the back-conversion of ASP3258-AG, cooling and acidification were incorporated duri...
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| Format: | Article |
| Language: | English |
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Betasciencepress Publishers
2017-06-01
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| Series: | Journal of Applied Bioanalysis |
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| Online Access: | https://doi.org/10.17145/jab.17.006 |