Activation of phosphoinositide 3-kinase/Akt/mechanistic target of rapamycin pathway and response to everolimus in endocrine receptor-positive metastatic breast cancer – A retrospective pilot analysis and viewpoint

Activation of phosphoinositide 3-kinase/Akt/mechanistic target of rapamycin pathway and response to everolimus in endocrine receptor-positive metastatic breast cancer – A retrospective pilot analysis and viewpoint

Introduction: Biomarkers predictive of response to mechanistic target of rapamycin (mTOR) inhibitor, everolimus, in endocrine receptor (ER)-positive metastatic breast cancer (MBC) are a work in progress. We evaluated the feasibility of directly measuring mTOR activity and phosphatase and tensin homo...

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Bibliographic Details
Main Authors: Jyoti Bajpai, Anant Ramaswamy, Arun Chandrasekharan, Surya Mishra, Tanuja Shet, Sudeep Gupta, R A Badwe
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2017-01-01
Series:South Asian Journal of Cancer
Subjects:
Everolimus
mechanistic target of rapamycin
metastatic breast cancer
phosphatase and tensin homolog
Online Access:http://journal.sajc.org/article.asp?issn=2278-330X;year=2017;volume=6;issue=3;spage=102;epage=105;aulast=Bajpai

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http://journal.sajc.org/article.asp?issn=2278-330X;year=2017;volume=6;issue=3;spage=102;epage=105;aulast=Bajpai

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