Possible A2E Mutagenic Effects on RPE Mitochondrial DNA from Innovative RNA-Seq Bioinformatics Pipeline

Possible A2E Mutagenic Effects on RPE Mitochondrial DNA from Innovative RNA-Seq Bioinformatics Pipeline

Mitochondria are subject to continuous oxidative stress stimuli that, over time, can impair their genome and lead to several pathologies, like retinal degenerations. Our main purpose was the identification of mtDNA variants that might be induced by intense oxidative stress determined by <i>N&l...

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Bibliographic Details
Main Authors: Luigi Donato, Concetta Scimone, Simona Alibrandi, Alessandro Pitruzzella, Federica Scalia, Rosalia D’Angelo, Antonina Sidoti
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
Mitochondria
mtDNA
RNA-Seq
Retinal degenerations
VUS
Online Access:https://www.mdpi.com/2076-3921/9/11/1158

Internet

https://www.mdpi.com/2076-3921/9/11/1158

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