Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease
While very rare familial forms of proteinopathy can cause Parkinson's disease (PD), Lewy body dementia (LBD) and age-related dementias, recent in-depth studies of lipid disturbances in the majority of the common forms of these diseases instead suggest a primary pathogenesis in lipid pathways. T...
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2019-10-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01053/full |
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doaj-bae86d2ecb374636844cf08dc5f1d4cc2020-11-25T01:18:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-10-011010.3389/fneur.2019.01053479126Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and DiseaseOle IsacsonOeystein R. BrekkPenelope J. HallettWhile very rare familial forms of proteinopathy can cause Parkinson's disease (PD), Lewy body dementia (LBD) and age-related dementias, recent in-depth studies of lipid disturbances in the majority of the common forms of these diseases instead suggest a primary pathogenesis in lipid pathways. This review synthesizes a perspective from new data that point to an interdependence of lipids and proteinopathy. This article describes disturbed relationships in lipid homeostasis that causes neuropathology to develop over time and with age, which includes altered mechanisms of glia-neuron exchange of lipids and inflammatory signals.https://www.frontiersin.org/article/10.3389/fneur.2019.01053/fullneuronslipidsastrocytesmicrogliainflammationα-synuclein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ole Isacson Oeystein R. Brekk Penelope J. Hallett |
spellingShingle |
Ole Isacson Oeystein R. Brekk Penelope J. Hallett Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease Frontiers in Neurology neurons lipids astrocytes microglia inflammation α-synuclein |
author_facet |
Ole Isacson Oeystein R. Brekk Penelope J. Hallett |
author_sort |
Ole Isacson |
title |
Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease |
title_short |
Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease |
title_full |
Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease |
title_fullStr |
Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease |
title_full_unstemmed |
Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease |
title_sort |
novel results and concepts emerging from lipid cell biology relevant to degenerative brain aging and disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-10-01 |
description |
While very rare familial forms of proteinopathy can cause Parkinson's disease (PD), Lewy body dementia (LBD) and age-related dementias, recent in-depth studies of lipid disturbances in the majority of the common forms of these diseases instead suggest a primary pathogenesis in lipid pathways. This review synthesizes a perspective from new data that point to an interdependence of lipids and proteinopathy. This article describes disturbed relationships in lipid homeostasis that causes neuropathology to develop over time and with age, which includes altered mechanisms of glia-neuron exchange of lipids and inflammatory signals. |
topic |
neurons lipids astrocytes microglia inflammation α-synuclein |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.01053/full |
work_keys_str_mv |
AT oleisacson novelresultsandconceptsemergingfromlipidcellbiologyrelevanttodegenerativebrainaginganddisease AT oeysteinrbrekk novelresultsandconceptsemergingfromlipidcellbiologyrelevanttodegenerativebrainaginganddisease AT penelopejhallett novelresultsandconceptsemergingfromlipidcellbiologyrelevanttodegenerativebrainaginganddisease |
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