Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease

by Penelope J. Hallett, Simone Engelender, Ole Isacson
Published 2019-07-01

Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease

by Ole Isacson, Oeystein R. Brekk, Penelope J. Hallett
Published 2019-10-01

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

by Oeystein R. Brekk, Alyssa Moskites, Ole Isacson, Penelope J. Hallett
Published 2018-10-01

Advantages and Recent Developments of Autologous Cell Therapy for Parkinson’s Disease Patients

by Teresia M. Osborn, Penelope J. Hallett, James M. Schumacher, Ole Isacson
Published 2020-04-01

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

by Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett, Ole Isacson
Published 2021-01-01

Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients

by Penelope J. Hallett, Oliver Cooper, Damaso Sadi, Harold Robertson, Ivar Mendez, Ole Isacson
Published 2014-06-01

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

by Elizabeth B. Moloney, Alyssa Moskites, Eliza J. Ferrari, Ole Isacson, Penelope J. Hallett
Published 2018-12-01

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

by Penelope J. Hallett, Jesse R. McLean, Andrew Kartunen, J. William Langston, Ole Isacson
Published 2012-08-01

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

by Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt
Published 2019-11-01

Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

by Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt
Published 2020-01-01

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

by Joanna A. Korecka, Ria Thomas, Anthony J. Hinrich, Alyssa M. Moskites, Zach K. Macbain, Penelope J. Hallett, Ole Isacson, Michelle L. Hastings
Published 2020-09-01

The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies

by Arnar Astradsson, Bruce G. Jenkins, Ji-Kyung Choi, Penelope J. Hallett, Michele A. Levesque, Jack S. McDowell, Anna-Liisa Brownell, Roger D. Spealman, Ole Isacson
Published 2009-09-01

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

by Sian E. Davies, Penelope J. Hallett, Thomas Moens, Gaynor Smith, Emily Mangano, Hyoung Tae Kim, Alfred L. Goldberg, Ji-Long Liu, Ole Isacson, George K. Tofaris
Published 2014-04-01

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

by Gaynor A Smith, Emily M Rocha, Thomas Rooney, Pascal Barneoud, Jesse R McLean, Jonathan Beagan, Teresia Osborn, Madeleine Coimbra, Yongyi Luo, Penelope J Hallett, Ole Isacson
Published 2015-01-01

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

by Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett
Published 2020-08-01

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

by Emily M. Rocha, Gaynor A. Smith, Eric Park, Hongmei Cao, Eilish Brown, Melissa A. Hayes, Jonathan Beagan, Jesse R. McLean, Sarah C. Izen, Eduardo Perez-Torres, Penelope J. Hallett, Ole Isacson
Published 2015-10-01

Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

by Joanna A. Korecka, Sebastien Talbot, Teresia M. Osborn, Sherida M. de Leeuw, Simon A. Levy, Eliza J. Ferrari, Alyssa Moskites, Elise Atkinson, Francine M. Jodelka, Anthony J. Hinrich, Michelle L. Hastings, Clifford J. Woolf, Penelope J. Hallett, Ole Isacson
Published 2019-01-01