Optimizing Parkinson’s disease diagnosis: the role of a dual nuclear imaging algorithm

by J. William Langston, Jesse C. Wiley, Michele Tagliati
Published 2018-02-01

Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency

by Peggy S. Eis, Neng Huang, J. William Langston, Eli Hatchwell, Birgitt Schüle
Published 2020-10-01

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

by Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca, Patrik Brundin
Published 2018-05-01

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

by Penelope J. Hallett, Jesse R. McLean, Andrew Kartunen, J. William Langston, Ole Isacson
Published 2012-08-01

Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage

by Sally K. Mak, Y. Anne Huang, Shifteh Iranmanesh, Malini Vangipuram, Ramya Sundararajan, Loan Nguyen, J. William Langston, Birgitt Schüle
Published 2012-01-01

Environmental Risk Factors and Parkinson's Disease: Selective Degeneration of Nigral Dopaminergic Neurons Caused by the Herbicide Paraquat

by Alison L. McCormack, Mona Thiruchelvam, Amy B. Manning-Bog, Christine Thiffault, J.William Langston, Deborah A. Cory-Slechta, Donato A. Di Monte
Published 2002-07-01

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.

by Blake Byers, Branden Cord, Ha Nam Nguyen, Birgitt Schüle, Lief Fenno, Patrick C Lee, Karl Deisseroth, J William Langston, Renee Reijo Pera, Theo D Palmer
Published 2011-01-01

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.

by Adrian Flierl, Luís M A Oliveira, Lisandro J Falomir-Lockhart, Sally K Mak, Jayne Hesley, Frank Soldner, Donna J Arndt-Jovin, Rudolf Jaenisch, J William Langston, Thomas M Jovin, Birgitt Schüle
Published 2014-01-01

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

by Chuong B Do, Joyce Y Tung, Elizabeth Dorfman, Amy K Kiefer, Emily M Drabant, Uta Francke, Joanna L Mountain, Samuel M Goldman, Caroline M Tanner, J William Langston, Anne Wojcicki, Nicholas Eriksson
Published 2011-06-01

Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.

by Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Birgitt Schüle, Jeff Alexander, William Wallace, Glenda M Halliday, J William Langston, Scott Braxton, Ted Yednock, Thomas Shaler, Jennifer A Johnston
Published 2014-01-01

Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter

by Amy B. Manning-Boğ, W. Michael Caudle, Xiomara A. Perez, Stephen H. Reaney, Ronald Paletzki, Martha Z. Isla, Vivian P. Chou, Alison L. McCormack, Gary W. Miller, J. William Langston, Charles R. Gerfen, Donato A. DiMonte
Published 2007-08-01

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

by Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle
Published 2014-02-01

Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.

by Shyra J Gardai, Wenxian Mao, Birgitt Schüle, Michael Babcock, Sue Schoebel, Carlos Lorenzana, Jeff Alexander, Sam Kim, Heather Glick, Kathryn Hilton, J Kent Fitzgerald, Manuel Buttini, San-San Chiou, Lisa McConlogue, John P Anderson, Dale B Schenk, Frederique Bard, J William Langston, Ted Yednock, Jennifer A Johnston
Published 2013-01-01