Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease

by Desiree A. Piper, Danuta Sastre, Birgitt Schüle
Published 2018-04-01

Discovery of functional non-coding conserved regions in the α-synuclein gene locus [v2; ref status: indexed, http://f1000r.es/4v9]

by Lori Sterling, Michael Walter, Dennis Ting, Birgitt Schüle
Published 2014-12-01

Genetic and Environmental Factors Influence the Pleomorphy of <i>LRRK2</i> Parkinsonism

by Vinita G. Chittoor-Vinod, R. Jeremy Nichols, Birgitt Schüle
Published 2021-01-01

Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency

by Peggy S. Eis, Neng Huang, J. William Langston, Eli Hatchwell, Birgitt Schüle
Published 2020-10-01

The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders

by C. Alejandra Morato Torres, Zinah Wassouf, Faria Zafar, Danuta Sastre, Tiago Fleming Outeiro, Birgitt Schüle
Published 2020-08-01

Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage

by Sally K. Mak, Y. Anne Huang, Shifteh Iranmanesh, Malini Vangipuram, Ramya Sundararajan, Loan Nguyen, J. William Langston, Birgitt Schüle
Published 2012-01-01

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

by Herschel S Dhekne, Izumi Yanatori, Rachel C Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R Alessi, Suzanne R Pfeffer
Published 2018-11-01

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.

by Blake Byers, Branden Cord, Ha Nam Nguyen, Birgitt Schüle, Lief Fenno, Patrick C Lee, Karl Deisseroth, J William Langston, Renee Reijo Pera, Theo D Palmer
Published 2011-01-01

Correction: Pulse-Field capillary electrophoresis of repeat-primed PCR amplicons for analysis of large repeats in Spinocerebellar Ataxia Type 10.

by Vera Hashem, Anjana Tiwari, Brittani Bewick, Helio A G Teive, Mariana Moscovich, Birgitt Schüle, Khalaf Bushara, Matt Bower, Astrid Rasmussen, Yu-Chih Tsai, Tyson Clark, Karen McFarland, Tetsuo Ashizawa
Published 2020-01-01

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.

by Adrian Flierl, Luís M A Oliveira, Lisandro J Falomir-Lockhart, Sally K Mak, Jayne Hesley, Frank Soldner, Donna J Arndt-Jovin, Rudolf Jaenisch, J William Langston, Thomas M Jovin, Birgitt Schüle
Published 2014-01-01

Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.

by Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Birgitt Schüle, Jeff Alexander, William Wallace, Glenda M Halliday, J William Langston, Scott Braxton, Ted Yednock, Thomas Shaler, Jennifer A Johnston
Published 2014-01-01

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

by Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle
Published 2014-02-01

Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.

by Shyra J Gardai, Wenxian Mao, Birgitt Schüle, Michael Babcock, Sue Schoebel, Carlos Lorenzana, Jeff Alexander, Sam Kim, Heather Glick, Kathryn Hilton, J Kent Fitzgerald, Manuel Buttini, San-San Chiou, Lisa McConlogue, John P Anderson, Dale B Schenk, Frederique Bard, J William Langston, Ted Yednock, Jennifer A Johnston
Published 2013-01-01

Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles

by Luis D. Bernal-Conde, Luis D. Bernal-Conde, Rodrigo Ramos-Acevedo, Rodrigo Ramos-Acevedo, Mario A. Reyes-Hernández, Mario A. Reyes-Hernández, Andrea J. Balbuena-Olvera, Andrea J. Balbuena-Olvera, Ishbelt D. Morales-Moreno, Ishbelt D. Morales-Moreno, Rubén Argüero-Sánchez, Birgitt Schüle, Magdalena Guerra-Crespo, Magdalena Guerra-Crespo
Published 2020-01-01