TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer

TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer

Abstract Background Impairment of natural killer (NK) cell activity is an important mechanism of tumor immunoevasion. T cell immunoglobulin domain and mucin domain-3 (Tim-3) is an activation-induced inhibitory molecule, inducing effector lymphocyte exhaustion in chronic viral infection and cancers....

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Bibliographic Details
Main Authors: Yujia Zheng, Yu Li, Jingyao Lian, Huiyun Yang, Feng Li, Song Zhao, Yu Qi, Yi Zhang, Lan Huang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Translational Medicine
Subjects:
Tumor microenvironment
NK cells
Tim-3
TNF-α
Esophageal cancer
Online Access:http://link.springer.com/article/10.1186/s12967-019-1917-0

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http://link.springer.com/article/10.1186/s12967-019-1917-0

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