Intradermal Immunization of EBOV VLPs in Guinea Pigs Induces Broader Antibody Responses Against GP Than Intramuscular Injection

Intradermal Immunization of EBOV VLPs in Guinea Pigs Induces Broader Antibody Responses Against GP Than Intramuscular Injection

Ebolavirus (EBOV) infection in humans causes severe hemorrhagic fevers with high mortality rates that range from 30 to 80% as shown in different outbreaks. Thus the development of safe and efficacious EBOV vaccines remains an important goal for biomedical research. We have shown in early studies tha...

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Bibliographic Details
Main Authors: Ying Liu, Zhiyuan Wen, Ricardo Carrion, Jerritt Nunneley, Hilary Staples, Anysha Ticer, Jean L. Patterson, Richard W. Compans, Ling Ye, Chinglai Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
ebola
vaccine
intradermal immunization
antibody response
VLP
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00304/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00304/full

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