Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are unclear. Furthermore, the necessity of NL docking...

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Bibliographic Details
Main Authors: Breane G Budaitis, Shashank Jariwala, Dana N Reinemann, Kristin I Schimert, Guido Scarabelli, Barry J Grant, David Sept, Matthew J Lang, Kristen J Verhey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
microtubule
kinesin
force
molecular motor
neck linker
cover-neck bundle
Online Access:https://elifesciences.org/articles/44146

Internet

https://elifesciences.org/articles/44146

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