Combined PI3Kα-mTOR Targeting of Glioma Stem Cells

Combined PI3Kα-mTOR Targeting of Glioma Stem Cells

Abstract Glioblastoma (GBM) is the most common and lethal primary intrinsic tumour of the adult brain and evidence indicates disease progression is driven by glioma stem cells (GSCs). Extensive advances in the molecular characterization of GBM allowed classification into proneural, mesenchymal and c...

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Bibliographic Details
Main Authors: Frank D. Eckerdt, Jonathan B. Bell, Christopher Gonzalez, Michael S. Oh, Ricardo E. Perez, Candice Mazewski, Mariafausta Fischietti, Stewart Goldman, Ichiro Nakano, Leonidas C. Platanias
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78788-z

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https://doi.org/10.1038/s41598-020-78788-z

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