HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.

HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.

5-Aza-2'-deoxycytidine (5-aza-CdR) is used extensively as a demethylating agent and acts in concert with histone deacetylase inhibitors (HDACI) to induce apoptosis or inhibition of cell proliferation in human cancer cells. Whether the action of 5-aza-CdR in this synergistic effect results from...

Full description

Bibliographic Details
Main Authors: Guolin Chai, Lian Li, Wen Zhou, Lipeng Wu, Ying Zhao, Donglai Wang, Shaoli Lu, Yu Yu, Haiying Wang, Michael A McNutt, Ye-Guang Hu, Yingqi Chen, Yang Yang, Xin Wu, Gregory A Otterson, Wei-Guo Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18560576/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18560576/pdf/?tool=EBI

Similar Items