Influenza Vaccine Manufacturing: Effect of Inactivation, Splitting and Site of Manufacturing. Comparison of Influenza Vaccine Production Processes.

The aim of this study was to evaluate the impact of different inactivation and splitting procedures on influenza vaccine product composition, stability and recovery to support transfer of process technology. Four split and two whole inactivated virus (WIV) influenza vaccine bulks were produced and c...

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Bibliographic Details
Main Authors: Theone C Kon, Adrian Onu, Laurentiu Berbecila, Emilia Lupulescu, Alina Ghiorgisor, Gideon F Kersten, Yi-Qing Cui, Jean-Pierre Amorij, Leo Van der Pol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4784929?pdf=render