The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain.

The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain.

Yra1 is an mRNA export adaptor involved in mRNA biogenesis and export in S. cerevisiae. Yra1 overexpression was recently shown to promote accumulation of DNA:RNA hybrids favoring DNA double strand breaks (DSB), cell senescence and telomere shortening, via an unknown mechanism. Yra1 was also identifi...

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Bibliographic Details
Main Authors: Valentina Infantino, Evelina Tutucci, Noël Yeh Martin, Audrey Zihlmann, Varinia Garcia-Molinero, Géraldine Silvano, Benoit Palancade, Françoise Stutz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0206336

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https://doi.org/10.1371/journal.pone.0206336

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