R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways

R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways

Wnt-mediated signals are involved in many important steps in mammalian regeneration. In multiple cell types, the R-spondin (Rspo) family of secreted proteins potently activates the canonical Wnt/β-catenin pathway. Here, we identify Rspo1 as a mediator of skeletal muscle tissue repair. First, we show...

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Bibliographic Details
Main Authors: Floriane Lacour, Elsa Vezin, C. Florian Bentzinger, Marie-Claude Sincennes, Lorenzo Giordani, Arnaud Ferry, Robert Mitchell, Ketan Patel, Michael A. Rudnicki, Marie-Christine Chaboissier, Anne-Amandine Chassot, Fabien Le Grand
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
skeletal muscle
canonical Wnt signaling
non-canonical Wnt signaling
R-spondin
regeneration
muscle satellite cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302176

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http://www.sciencedirect.com/science/article/pii/S2211124717302176

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