Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression

Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression

Major depressive disorder has become a prominent cause of disability, as lifetime prevalence has increased to ~15% in the Western world. Pharmacological effects of serotonin (5-hydroxytryptamine, 5-HT) are mediated through 5-hydroxytryptamine receptor (5-HTR) binding. Serotonin regulation of amygdal...

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Bibliographic Details
Main Authors: Taichi Ochi, Natalya M. Vyalova, Innokentiy S. Losenkov, Diana Z. Paderina, Ivan V. Pozhidaev, Anton J. M. Loonen, German G. Simutkin, Nikolay A. Bokhan, Svetlana A. Ivanova, Bob Wilffert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
5-HT receptor genes
treatment response
polymorphism
antidepressant
treatment-free depression
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01462/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01462/full

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