Hypoxia-Induced miR-137 Inhibition Increased Glioblastoma Multiforme Growth and Chemoresistance Through LRP6

Hypoxia-Induced miR-137 Inhibition Increased Glioblastoma Multiforme Growth and Chemoresistance Through LRP6

PurposeGlioblastoma multiforme (GBM) is one of the deadliest tumors, which is involved in numerous dysregulated microRNAs including miR-137. However, the mechanism of how miR-137 suppression associated with cancer progression and chemoresistance still remains to be elucidated.MethodsQuantitative rev...

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Bibliographic Details
Main Authors: Dong-Mei Li, Qiu-Dan Chen, Gui-Ning Wei, Jie Wei, Jian-Xing Yin, Jun-Hui He, Xin Ge, Zhu-Mei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
glioblastoma multiforme
miR-137
chemoresistance
LRP6
epithelial-mesenchymal transition-related genes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.611699/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.611699/full

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