Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

<p>Abstract</p> <p>Background</p> <p>The Wnt/β-catenin signalling is aberrantly activated in primary B cell chronic lymphocytic leukaemia (CLL). Epigenetic silencing of pathway inhibitor genes may be a mechanism for its activation. In this study, we investigated systema...

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Bibliographic Details
Main Authors: Moskalev Evgeny A, Luckert Katrin, Vorobjev Ivan A, Mastitsky Sergey E, Gladkikh Aleena A, Stephan Achim, Schrenk Marita, Kaplanov Kamil D, Kalashnikova Olga B, Pötz Oliver, Joos Thomas O, Hoheisel Jörg D
Format: Article
Language:English
Published: BMC 2012-06-01
Series:BMC Cancer
Subjects:
B cell chronic lymphocytic leukaemia
Wnt/β-catenin pathway
Inhibitor genes
DNA hypermethylation
Epigenetic silencing
β-catenin
Online Access:http://www.biomedcentral.com/1471-2407/12/213

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http://www.biomedcentral.com/1471-2407/12/213

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