Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine.

Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine.

One promising new Artemisinin-based combination therapies (ACTs) is dihydroartemisinin-piperaquine (DHA-PQ). However, the pharmacokinetics of piperaquine and the relationship between drug levels and clinical efficacy are incompletely characterized, particularly in children.We performed a single-arm...

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Bibliographic Details
Main Authors: Issaka Zongo, Fabrice A Somé, Serge A M Somda, Sunil Parikh, Noel Rouamba, Philip J Rosenthal, Joel Tarning, Niklas Lindegardh, François Nosten, Jean Bosco Ouédraogo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4136730?pdf=render

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http://europepmc.org/articles/PMC4136730?pdf=render

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