Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization

Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization

Adenosine, an immunomodulatory biomolecule, is produced by the ecto-enzymes CD39 (nucleoside triphosphate dephosphorylase) and CD73 (ecto-5'-nucleotidase) by dephosphorylation of extracellular ATP. CD73 is expressed by many cell types during injury, infection and during steady-state conditions....

Full description

Bibliographic Details
Main Authors: M. Samiul Alam, Matthew G. Costales, Christopher Cavanaugh, Kristina Williams
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Biomolecules
Subjects:
adenosine
CD39
CD73
adenosine receptors
immune response
lymphocytes
macrophage
bacterial-persistence
inflammation
cytokine
Online Access:http://www.mdpi.com/2218-273X/5/2/775

Internet

http://www.mdpi.com/2218-273X/5/2/775

Similar Items