Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice

Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice

Current models stipulate that B cells and antibodies function during atherosclerosis in two distinct ways based on antibody isotype, where IgM is protective and IgG is inflammatory. To examine this model, we generated ApoE-/- Aid-/- mice, which are unable to produce IgG antibodies due to the absence...

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Bibliographic Details
Main Authors: Mark A. Hutchinson, Han-Sol Park, Kimberly J. Zanotti, Juan Alvarez-Gonzalez, Jing Zhang, Li Zhang, Richard Telljohann, Mingyi Wang, Edward G. Lakatta, Patricia J. Gearhart, Robert W. Maul
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
AID
atherosclerosis
B cells
antibodies
antigens
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.695220/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.695220/full

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