Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices

In human disease, channelopathies involving functional reduction of the delayed rectifier potassium channel α-subunit Kv1.1 – either by mutation or autoimmune inhibition – result in temporal lobe epilepsy. Kv1.1 is prominently expressed in the axons of the hippocampal tri-synaptic pathway, suggestin...

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Bibliographic Details
Main Authors: Timothy A. Simeone, Kristina A. Simeone, Kaeli K. Samson, Do Young Kim, Jong M. Rho
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000715