Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages

Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages

Many studies report the adverse responses to metal-on-metal (MoM) hip prostheses, with tissues surrounding failed MoM hip prostheses revealing abundant tissue necrosis and fibrosis. These local effects appear to be initiated by metal ions released from the prosthesis causing the secretion of inflamm...

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Bibliographic Details
Main Authors: J Xu, A Nyga, W Li, X Zhang, N Gavara, MM Knight, JC Shelton
Format: Article
Language:English
Published: AO Research Institute Davos 2018-10-01
Series:European Cells & Materials
Subjects:
Cobalt chromium
fibroblast
extracellular matrix
cell mechanics
reactive oxygen species
fibrosis.
Online Access:http://www.ecmjournal.org/papers/vol036/pdf/v036a11.pdf

Internet

http://www.ecmjournal.org/papers/vol036/pdf/v036a11.pdf

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