Brain Transcriptomic Analysis of Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type

Brain Transcriptomic Analysis of Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type

Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln) in the amyloid precursor protein (APP). Post-mortem frontal and occipital...

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Bibliographic Details
Main Authors: Laure Grand Moursel, Willeke M. C. van Roon-Mom, Szymon M. Kiełbasa, Hailiang Mei, Henk P. J. Buermans, Linda M. van der Graaf, Kristina M. Hettne, Emile J. de Meijer, Sjoerd G. van Duinen, Jeroen F. J. Laros, Mark A. van Buchem, Peter A. C. ‘t Hoen, Silvère M. van der Maarel, Louise van der Weerd
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
RNA sequencing and transcriptome analysis
hereditary cerebral hemorrhage with amyloidosis-Dutch type
familial cerebral amyloid angiopathy
E22Q amyloid β
E693Q mutation
extracellular matrix remodeling
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00102/full

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http://journal.frontiersin.org/article/10.3389/fnagi.2018.00102/full

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