BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

Abstract Background Mammary cancer is highly prevalent in dogs and cats and results in a poor prognosis due to critically lacking viable treatment options. Recent human and mouse studies have suggested that inhibiting peptidyl arginine deiminase enzymes (PAD) may be a novel breast cancer therapy. Ba...

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Bibliographic Details
Main Authors: Melissa M. Ledet, Robyn Anderson, Rebecca Harman, Aaron Muth, Paul R. Thompson, Scott A. Coonrod, Gerlinde R. Van de Walle
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Peptidyl arginine deiminase
Endoplasmic reticulum stress
Mammary cancer
BB-cl-Amidine
Online Access:http://link.springer.com/article/10.1186/s12885-018-4323-8

Internet

http://link.springer.com/article/10.1186/s12885-018-4323-8

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