Prion uptake in the gut: identification of the first uptake and replication sites.

Prion uptake in the gut: identification of the first uptake and replication sites.

After oral exposure, prions are thought to enter Peyer's patches via M cells and accumulate first upon follicular dendritic cells (FDCs) before spreading to the nervous system. How prions are actually initially acquired from the gut lumen is not known. Using high-resolution immunofluorescence a...

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Bibliographic Details
Main Authors: Pekka Kujala, Claudine R Raymond, Martijn Romeijn, Susan F Godsave, Sander I van Kasteren, Holger Wille, Stanley B Prusiner, Neil A Mabbott, Peter J Peters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3245311?pdf=render

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http://europepmc.org/articles/PMC3245311?pdf=render

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