In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment

In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment

Activation of immune cells is under control of immunological and physiological regulatory mechanisms to ensure adequate destruction of pathogens with the minimum collateral damage to innocent bystander cells. The concept of physiological negative regulation of immune response has been advocated bas...

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Bibliographic Details
Main Authors: Akio eOhta, Rohan eDiwanji, Radhika eKini, Meenakshi eSubramanian, Akiko eOhta, Michail eSitkovsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Immunology
Subjects:
Hyperoxia
Oxygen
tumor
hypoxia
T cell
Cytometry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00027/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00027/full

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