Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4

Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4

Background: Oral commensals contribute to microbe-host symbiosis in periodontal homeostasis, and Porphyromonas gingivalis (P. gingivalis) as the keystone pathogen critically accounts for the shift of symbiosis to dysbiosis and periodontal destruction. Nucleotide-binding oligomerization domain (NOD)-...

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Bibliographic Details
Main Authors: Pei-Hui Ding, Meng-Xin Yang, Na-Na Wang, Li-Jian Jin, Yan Dong, Xia Cai, Li-Li Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
NLRP3 inflammasome
Caspase-1
Caspase-11
pathogenic bacteria
commensal bacteria
adenosine 5'-triphosphate
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01881/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01881/full

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