Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis

Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis

To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small GTPases Arf and Rac1, and the Arf1 activator ARNO...

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Bibliographic Details
Main Authors: Daniel Humphreys, Vikash Singh, Vassilis Koronakis
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
SCAR complex
Rho GTPase
virulence effector
type 3 secretion system
ADP-ribosylation factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312785

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http://www.sciencedirect.com/science/article/pii/S2211124716312785

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