Hypoxic Conditioned Medium from Human Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Skin Wound Healing through TGF-β/SMAD2 and PI3K/Akt Pathways

Hypoxic Conditioned Medium from Human Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Skin Wound Healing through TGF-β/SMAD2 and PI3K/Akt Pathways

In a previous study, we isolated human amniotic fluid (AF)-derived mesenchymal stem cells (AF-MSCs) and utilized normoxic conditioned medium (AF-MSC-norCM) which has been shown to accelerate cutaneous wound healing. Because hypoxia enhances the wound healing function of mesenchymal stem cell-conditi...

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Bibliographic Details
Main Authors: Eun Kyoung Jun, Qiankun Zhang, Byung Sun Yoon, Jai-Hee Moon, Gilju Lee, Gyuman Park, Phil Jun Kang, Jung Han Lee, Areee Kim, Seungkwon You
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
amniotic fluid-derived mesenchymal stem cells (AF-MSCs)
wound healing
PI3K/AKT
TGF-β/SMAD2
Online Access:http://www.mdpi.com/1422-0067/15/1/605

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http://www.mdpi.com/1422-0067/15/1/605

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