Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment

Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment

Current cancer therapeutics suffer from a lack of specificity in targeting tumor cells and cause severe side effects. Therefore, the design of highly specialized drugs comprising antibody derivatives inducing apoptosis in targeted cancer cells is considered to be a promising strategy. Drugs acting o...

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Bibliographic Details
Main Authors: Golnaz Sadeghnezhad, Ema Romão, Robert Bernedo-Navarro, Sam Massa, Khosro Khajeh, Serge Muyldermans, Sadegh Hassania
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
death receptor 5
nanobody
trail
cancer therapy
apoptosis
Online Access:https://www.mdpi.com/1422-0067/20/19/4818

Internet

https://www.mdpi.com/1422-0067/20/19/4818

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