Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

The membrane attack complex (MAC) of the complement system and Perforin-1 are well characterized innate immune effectors. MAC is composed of C9 and other complement proteins that target the envelope of gram-negative bacteria. Perforin-1 is deployed when killer lymphocytes degranulate to destroy vira...

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Bibliographic Details
Main Authors: Leidy C. Merselis, Zachary P. Rivas, George P. Munson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
pore-forming protein
MACPF/CDC family proteins
innate immune effector
phagosome
phagocyte
perforin-2/MPEG1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.597951/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.597951/full

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