Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

Dap12 and FcRγ, the two transmembrane ITAM-containing signaling adaptors expressed in dendritic cells (DC), are implicated in the regulation of DC function. Several activating and adhesion receptors including integrins require these chains for their function in triggering downstream signaling and ef...

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Bibliographic Details
Main Authors: Grzegorz B Gmyrek, Holly M Akilesh, Daniel B Graham, Anja Fuchs, Lihua Yang, Mark J Miller, Gabriel J Sandoval, Kathleen C F Sheehan, Robert D Schreiber, Michael S Diamond, Wojciech Swat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3796521?pdf=render

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