Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

Ping Fang,1 Xiang Zheng,1 Jiayang He,1 Honglei Ge,1 Pengfei Tang,1 Jianping Cai,2 Guoxin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, 2The Ministry of Health (MOH) Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology,...

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Bibliographic Details
Main Authors: Fang P, Zheng X, He JY, Ge HL, Tang PF, Cai JP, Hu GX
Format: Article
Language:English
Published: Dove Medical Press 2017-04-01
Series:Drug Design, Development and Therapy
Subjects:
CYP2D6
genetic polymorphism
drug metabolism
gefitinib
enzymatic activity
Online Access:https://www.dovepress.com/functional-characterization-of-wild-type-and-24-cyp2d6-allelic-variant-peer-reviewed-article-DDDT

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https://www.dovepress.com/functional-characterization-of-wild-type-and-24-cyp2d6-allelic-variant-peer-reviewed-article-DDDT

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