Proteasome inhibition is partially effective in attenuating pre-existing immunity against recombinant adeno-associated viral vectors.

Proteasome inhibition is partially effective in attenuating pre-existing immunity against recombinant adeno-associated viral vectors.

Pre-existing immunity against adeno-associated virus (AAV) remains a major challenge facing the clinical use of systemic administration of recombinant AAV vectors for the treatment of genetic and acquired diseases using gene therapy. In this study, we evaluated the potential of bortezomib (marketed...

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Bibliographic Details
Main Authors: Jozsef Karman, Nathan K Gumlaw, Jinhua Zhang, Ji-Lei Jiang, Seng H Cheng, Yunxiang Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3326043?pdf=render

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http://europepmc.org/articles/PMC3326043?pdf=render

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