Persistence <em>versus</em> Reversion of 3TC Resistance in HIV-1 Determine the Rate of Emergence of NVP Resistance

Persistence <em>versus</em> Reversion of 3TC Resistance in HIV-1 Determine the Rate of Emergence of NVP Resistance

When HIV-1 is exposed to lamivudine (3TC) at inhibitory concentrations, resistant variants carrying the reverse transcriptase (RT) substitution M184V emerge rapidly. This substitution confers high-level 3TC resistance and increased RT fidelity. We established a novel <em>in vitro&l...

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Bibliographic Details
Main Authors: Barbara A. Rath, Richard A. Olshen, Jerry Halpern, Thomas C. Merigan
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Viruses
Subjects:
HIV-1
lamivudine
nevirapine
adefovir
resistance
selection
serial passage
Online Access:http://www.mdpi.com/1999-4915/4/8/1212

Internet

http://www.mdpi.com/1999-4915/4/8/1212

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