Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation

Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation

Abstract Background Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences. Here, we f...

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Bibliographic Details
Main Authors: Shan Li, Evgeny Z. Kvon, Axel Visel, Len A. Pennacchio, Ivan Ovcharenko
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Genome Biology
Subjects:
Enhancer
Evolution of gene regulation
Transcription factor interaction
Causal regulatory variants
Transgenic mouse reporter assay
Online Access:http://link.springer.com/article/10.1186/s13059-019-1750-z

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http://link.springer.com/article/10.1186/s13059-019-1750-z

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