Identifying and predicting Parkinson's disease subtypes through trajectory clustering via bipartite networks.

Chronic medical conditions show substantial heterogeneity in their clinical features and progression. We develop the novel data-driven, network-based Trajectory Profile Clustering (TPC) algorithm for 1) identification of disease subtypes and 2) early prediction of subtype/disease progression pattern...

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Bibliographic Details
Main Authors: Sanjukta Krishnagopal, Rainer von Coelln, Lisa M Shulman, Michelle Girvan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0233296